Labels:text | screenshot | black and white | black | font | document OCR: Molecular biological techniques have be en our employed with considerable effect to wi knowledge of the structure of the steroid of action hydroxylase genes and of the mechanisr d P450 C21 of ACTH. Human P450 scc, P450 C17ow, a ome 2kb in are encoded by a single mRNA species, s pree length. Bovine P450 C11ß is encoded by length. mRNAs, with the smallest being 4.3kb i (or cAMP) Exposure of adrenocortical cells to ACTI causes the accumulation of all four P450 nodoxin steroidogenic enzymes, as well as of adr sure to and adrenodoxin reductase. Chronic exp s for ACTH involves transcription of the ger steroid hydroxylases.
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